Product Details
| Product Name:
Dersimelagon |
CAS No.:
1835256-48-8 |
| Purity:
98.23% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Dersimelagon |
| Description | Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values ??of 8.16, 3.91, 1.14, and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m), and rat (r) MC1R, respectively. Dersimelagon exhibits good affinity for hMC1R and hMC4R, with Ki values ??of 2.26 and 32.9 nM, respectively. Dersimelagon can be used in the study of skin pigmentation[1]. |
| In vitro | METHODS: B16F1 cells were treated with Dersimelagon (MT-7117) (0, 0.03, 0.1, 0.3, 1, 3, 10, 30, 100, 300 pM; 3 days) to evaluate the ability of Dersimelagon (MT-7117) to induce eumelanin production.
RESULTS Dersimelagon (MT-7117) increased eumelanin production in a concentration-dependent manner with an EC50 of 13 pM in B16F1 cells. [1] |
| In vivo | METHODS: Dersimelagon (MT-7117) (0.003, 0.03, 0.3, 3 mg/kg; oral administration for 6 days) was used to observe the effect of Dersimelagon (MT-7117) on the hair of Ay/a mice.
RESULTS MT-7117 induced the synthesis of eumelanin, but not pheomelanin, in the hair roots of Ay/a mice. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 6.76 mg/mL (10 mM), Sonication is recommended.
|
| Keywords | MT7117 | Dersimelagon | MT 7117 |
| Inhibitors Related | HS 014 acetate(207678-81-7 free base) | MCL0020 | Beta-MSH (1-22) (human) acetate | ACTH (1-17) acetate | Neuropeptide EI, rat acetate | [D-Trp8]-γ-MSH acetate(321351-81-9 free base) | a-MSH, amide Acetate(581-05-5 free base) | Undecylenoyl phenylalanine | ACTH 11-24 acetate(4237-93-8 free base) | Melanotan (MT)-II | HS024 | Nonapeptide-1 acetate salt (158563-45-2 free base) |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:2070014-93-4
$39.00 / 5mg
-
CAS:2756-87-8
$42.00 / 500mg
-
CAS:19881-70-0
$40.00 / 5mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1900.00/1g |
|
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
|
2024-01-25 |
United States