Dehydrocorydaline chloride NEW
| Price | $53 | $113 | $163 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Dehydrocorydaline chloride | CAS No.: 10605-03-5 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Dehydrocorydaline chloride |
| Description | Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid exhibiting anti-inflammatory and anti-cancer activities and can enhance the activation of p38 MAPK. |
| In vitro | Treatment of C2C12 myoblasts with 500 nM dehydrocorydrine increased the expression of muscle-specific proteins (including MyoD, myogenin, and myosin heavy chain), and enhanced p38 MAPK activation and the interaction between MyoD and E protein. Additionally, dehydrohydroxyproline restored defects in differentiation-induced p38 MAPK activation and differentiation of myoblasts caused by Cdo. Dehydrohydroxyproline significantly inhibited MCF-7 cell proliferation in a dose-dependent manner, reversible by the caspase-8 inhibitor Z-IETD-FMK. It also increased DNA fragmentation without affecting ΔΨm, elevated Bax protein levels, decreased Bcl-2 protein levels, and induced caspase-7 and -8 activation and PARP cleavage, without affecting caspase-9. These findings suggest that dehydrohydroxyproline inhibits MCF-7 cell proliferation by inducing apoptosis through Bax/Bcl-2 regulation, caspase activation, and PARP cleavage. |
| In vivo | Dehydrocobaltate (3.6, 6 or 10 mg/kg, intraperitoneal injection) showed a dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test and significantly reduced formalin-induced mice Pain reaction. In the formalin test, dehydrocorydrine can reduce the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. It was confirmed that dehydroyanhusine has an analgesic effect on mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 24 mg/mL (59.72 mM) |
| Keywords | inhibit | Bcl-2 Family | Dehydrocorydaline chloride | Dehydrocorydaline Chloride | Autophagy | PARP | poly ADP ribose polymerase | Caspase | 13-Methylpalmatine | Dehydrocorydaline | p38 MAPK | 13-Methylpalmatine Chloride | Parasite | Inhibitor |
| Inhibitors Related | Hydroxychloroquine | Guanidine hydrochloride |
| Related Compound Libraries | Anti-Parasitic Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Natural Product Library | Antiparasitic Natural Product Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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