Product Details
| Product Name:
Deferitazole |
CAS No.:
945635-15-4 |
| Purity:
98.26% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Deferitazole |
| Description | Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator. |
| In vitro | Deferitazole (FBS0701) displays a high affinity and selectivity for iron(III) as demonstrated by the log?β2 = 33.39 ± 0.03 and the pFe(3+) value of 22.3. Two equilibrating isomeric forms of the iron(III) complex exist under biological conditions. Deferitazole also binds the trivalent metals Al(III) and La(III) with high affinity; log?β2 values, 26.68 and 21.55 respectively. The affinity of Deferitazole for divalent cations is somewhat lower, with the exception of Cu(II) which possesses a log?β2 value of 25.5; Deferitazole scavenges iron from labile sources such as citrate and albumin with efficiencies comparable with those of other therapeutic iron chelators, including deferasirox, deferiprone and desferrioxamine. The Fe(III)(Deferitazole)2 is stable under physiological conditions and does not redox cycle. The high affinity of Deferitazole for iron(III) renders it unlikely that this chelator will lead to the redistribution of iron and consequently Deferitazole shows considerable promise as a therapeutic iron(III) chelator.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (125.17 mM)
|
| Keywords | Deferitazole |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1520.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
United States