Deferiprone NEW
| Price | $42 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Deferiprone | CAS No.: 30652-11-0 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Deferiprone |
| Description | Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity. |
| In vitro | At a concentration of 1 mM, Deferiprone causes a significant decrease in complex I-III activity in iron-overloaded cardiomyocytes. It exhibits cytotoxic effects on human tumor cell lines HSC-2, HSC-3, and HL-60, with IC50 values of 13.5 μg/mL, 9.9 μg/mL, and 10.6 μg/mL, respectively. The cytotoxicity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl3. At 100 μg/mL, Deferiprone induces inter-nucleosomal DNA fragmentation in HL-60 cells, a process inhibited by the addition of FeCl3. Protection of myocytes from doxorubicin-induced lactate dehydrogenase release is observed with 100 μM Deferiprone. It effectively inhibits the transfer of radiolabeled iron from iron-loaded cardiomyocytes and protects or restores mitochondrial respiratory enzyme activity in a xanthine oxidase/hypoxanthine superoxide generating system at a concentration of 0.3 mM. Furthermore, 0.5 mM Deferiprone enhances the clearance of free iron from RBC membranes in a time- and dose-dependent manner. A 3 mM concentration significantly reduces hydroxyl radical production from the iron(III)-adriamycin complex in the xanthine oxidase/hypoxanthine superoxide generating system. |
| In vivo | Administration of 100 mg/kg Deferiprone resulted in a 24% reduction in the average cross-sectional area of the basilar artery in rabbits. When combined with subarachnoid hemorrhage (SAH), Deferiprone also demonstrated variability in the waviness of the internal elastic lamina in rabbits. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 2.17 mg/mL (15.62 mM), Sonication is recommended. H2O : 8.33 mg/mL (59.86 mM), Sonication is recommended. |
| Keywords | Ferroptosis | HCV | inhibit | Inhibitor | Hepatitis C virus | CP 20 | CP-20 | Deferiprone |
| Inhibitors Related | TBHQ | Methyl 2-amino-5-bromobenzoate | Butylated hydroxytoluene | α-Vitamin E | Ribavirin | Sorafenib | L-Glutathione reduced | Curcumin | Artemisinin | L-Cystine | L-Glutamic acid monosodium salt | Coenzyme Q10 |
| Related Compound Libraries | Bioactive Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $100.00/25KG |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-10-31 | |
| $0.00/1Kg |
VIP4Y
|
Henan Research New Materials Co., Ltd.
|
2024-07-22 | |
| $1.00/1KG |
Ouhuang Engineering Materials (Hubei) Co., Ltd
|
2024-04-29 | ||
| $0.00/1KG |
VIP2Y
|
shandong perfect biotechnology co.ltd
|
2023-07-04 | |
| $1.00/1kg |
Hubei Langyou International Trading Co., Ltd
|
2023-03-10 | ||
| $0.00/1kg |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-10-19 | |
| $1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-09-24 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-08-11 | ||
| $0.00/20KG |
Qiuxian Baitai New Material Co., LTD
|
2021-03-19 | ||
| $0.00/1Kg |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-05-25 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY