CZC-54252 hydrochloride NEW
Price | $44 | $69 | $137 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-11 |
Product Details
Product Name: CZC-54252 hydrochloride | CAS No.: 1784253-05-9 |
Purity: 98.21% | Supply Ability: 10g |
Release date: 2024/11/11 |
Product Introduction
Bioactivity
名稱 | CZC-54252 hydrochloride |
描述 | CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM. |
體外活性 | CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay[2]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 30 mg/mL (55.41 mM), Sonication and heating to 60℃ are recommended. |
關(guān)鍵字 | CZC 54252 | CZC54252 hydrochloride | injury | inhibit | LRRK2 | CZC54252 | CZC-54252 | neuronal | Leucine-rich repeat kinase 2 | neuroprotective | CZC-54252 Hydrochloride | Inhibitor | CZC 54252 hydrochloride | CZC 54252 Hydrochloride | LRRK2-G2019S | CZC54252 Hydrochloride |
相關(guān)產(chǎn)品 | PFE-360 | GNE0877 | CZC-25146 | GSK2578215A | GNE-9605 | GNE-7915 | EB-42486 | LRRK2 inhibitor 1 | LRRK2-IN-7 | LRRK2-IN-1 | CCG-1423 | PF-06454589 |
相關(guān)庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抑制劑庫 | 神經(jīng)保護(hù)化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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