Cuminaldehyde NEW
| Price | $43 |
| Package | 5g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Cuminaldehyde | CAS No.: 122-03-2 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Cuminaldehyde |
| Description | Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essential oils. |
| Cell Research | Incubated the cells in the culture plate with 96 wells at the concentration of ten thousand cells per well.?After being incubated for 24 h, we treated the cells with cuminaldehyde at the concentration of 10, 20, 40, 80, or 160 μM for 12, 24, or 48 h. Determined cell viability using the Cell Proliferation Kit II (XTT) according to the supplier's instructions.?The value of absorbance was evaluated by a spectrophotometer (Tecan infinite M200, Tecan, M?nnedorf, Switzerland) using 492 nm wavelength with a reference of 650 nm wavelength[1]. |
| Animal Research | Human colorectal COLO 205 cells (5 × 10^6 cells in 200 μL of culture medium) were subcutaneously injected into the mice's flanks.?Treatment was started when the tumors reached about 75 mm^3.?Thirty-two mice were divided randomly into four groups (eight mice/group).?Cuminaldehyde-treated mice received intratumoral injection of 5, 10, or 20 mg/kg/day of cuminaldehyde in a 200 μL volume (the solutions were prepared from stock solution of cuminaldehyde in dimethyl sulfoxide and diluted into appropriate concentrations in PBS) daily.?The mice in the control group were treated with an equal volume of vehicle.?After transplantation, body weight as well as tumor size were monitored at weekly intervals.?Tumor size was measured using calipers, and tumor volume was calculated using the hemiellipsoid model formula[1] |
| In vitro | Cuminaldehyde?suppressed growth and induced apoptosis, as proved by depletion of the mitochondrial membrane potential, activation of both caspase-3 and -9, and morphological features of apoptosis[1]. |
| In vivo | In vivo, cuminaldehyde diminished the tumor burden ,cuminaldehyde could be a drug for chemopreventive or anticancer therapy[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (168.69 mM) |
| Keywords | Cuminaldehyde | Inhibitor | Endogenous Metabolite | inhibit |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Oleamide | Glycerol | Thymidine | Naringin |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Flavor Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Tobacco Monomer Library | Inhibitor Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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