Product Details
| Product Name:
CS1 |
CAS No.:
1448009-94-6 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | CS1 |
| Description | CS1 is a potent DNA Topo II α inhibitor that exhibits broad-spectrum antitumor effects in vitro, low toxicity in vivo, and potential anti-multidrug resistance capabilities. CS1 induces DNA damage, G2/M phase cell cycle arrest, and apoptosis [1]. |
| In vitro | CS1 exhibits cytotoxicity with IC50 values of 16.92 and 18.88 μM for MCF-7 and MCF7/ADR cells, respectively [1]. CS1 (10, 50, 100 μM) inhibits topoisomerase IIα (Topo IIα) activity [1] and shows antiproliferative effects in cancer cells at concentrations ranging from 0-20 μM [1]. Additionally, CS1 (2.5, 5, 10 μM) induces G2/M phase cell cycle arrest and apoptosis [1], and at concentrations of 5, 10, and 15 μM for 24 hours, it causes DNA breaks in MDA-MB-231 cells [1]. Cell cycle analysis with MDA-MB-231 cells at 2.5, 5, and 10 μM concentrations revealed G2/M phase arrest, while apoptosis analysis showed induction of apoptosis [1]. |
| In vivo | CS1, administered intravenously at a dosage of 20 mg/kg every other day for two weeks, demonstrated antitumor activity [1]. This was observed in an animal model using five-week-old female athymic nude mice (BALB/c-nu) [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$133.00/1mg |
VIP3Y
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TargetMol Chemicals Inc.
|
2024-11-19 |
United States