CRK12-IN-1 NEW
| Price | $350 | $828 | $1130 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: CRK12-IN-1 | CAS No.: 1990479-14-5 |
| Purity: 99.29% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | CRK12-IN-1 |
| 描述 | CRK12-IN-1 is a potent CRK12 inhibitor with insecticidal activity and exhibits inhibitory effects on Trypanosoma brucei (T.b. brucei) and Trypanosoma congolense (T. congolense) with EC50s of 1.3 and 18 nM, respectively, rapidly killing the pathogenic cells. |
| 體外活性 | CRK12-IN-1(compound 1) (10 mg/mL; 69 h) demonstrates exceptional potency against T.b. brucei, proving highly effective in animal models of T.b. brucei infection. Additionally, it serves as a potent inhibitor of T. congolensei, with EC50 values of 1.3 and 18 nM, respectively.[1] |
| 體內(nèi)活性 | CRK12-IN-1 (compound 1) demonstrates moderate blood clearance and a short half-life (~1.8 h) in male ruminating Holstein-Friesian cattle, penetrating tissues beyond the vasculature (5 mg free base/kg, i.m. or 2.5 mg free base/kg, i.v.; 0.25-120 h). It reduces parasitemia in T. congolense-infected calves but does not prevent re-emergence after treatment ends (5 mg/kg, s.c., twice 12 h apart for 4 days). In female NMRI mice, CRK12-IN-1 shows 74% bioavailability and a half-life of ~1 h (10 mg free base/kg, s.c., 0.08-8 h). It achieves sterile cure against T. congolense in mice (50 or 10 mg/kg, s.c., once daily for 4 days) and is slightly more efficacious against T. vivax-infected mice (30 or 3 mg/kg, s.c., daily for 4 days). |
| 存儲條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (126.97 mM) |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Rifampicin | Ampicillin sodium | Doxycycline (hyclate) | Kanamycin sulfate | G-418 disulfate | Spectinomycin dihydrochloride | Sulfamethoxazole sodium | Metronidazole | Doxycycline | EDTA copper(II) disodium salt | Gentamicin sulfate |
| 相關(guān)庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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