Product Details
| Product Name:
Col003 |
CAS No.:
328565-16-8 |
| Purity:
99.03% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Col003 |
| 描述 | Col003 is a selective and potent inhibitor of Hsp47, competitively binding to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It is useful for researching fibrosis. |
| 體外活性 | A molecule AK778 and its cleavage product Col003 competitively inhibited the interaction and caused the inhibition of collagen secretion by destabilizing the collagen triple helix. Structural information obtained with NMR analysis revealed that Col003 competitively binds to the collagen-binding site on Hsp47. Col003 has an inhibitory effect on the interaction of Hsp47 with collagen in Hsp47 KO / MEFs. Col003 (0.01-100 μM) exhibits dose-dependent effects on the interactions of Hsp47 with collagen (IC50: 1.8 μM for Hsp47). Col003 (100 μM; 20-60 mins) has an inhibitory effect on collagen secretion and accumulation. It inhibits collagen secretion by wild-type MEFs and the secretion is not abolished completely. Col003 (100 μM) degrades α,α′-dipyridyl collagen secretion completely by incubation with trypsin at a high temperature (50 °C for 15 min), but is resistant to trypsin digestion at 37 °C. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (213.81 mM), Sonication is recommended.
|
| 關(guān)鍵字 | MEF | structure | Hsp47 | triple | helix | collagen | Col-003 | secretion | HSP | Heat shock proteins | Inhibitor | Col 003 | inhibit | Col003 | interaction |
| 相關(guān)產(chǎn)品 | Ethoxyquin | SNX0723 | Tamoxifen | DN401 | SNX2112 | Ganetespib | Teprenone | Elesclomol | Rifabutin | Palmitic acid | Paeoniflorin | Tamoxifen Citrate |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗乳腺癌化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 代謝化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 | 細胞骨架化合物庫 | 抗癌化合物庫 | 抗代謝疾病化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$39.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
United States