Product Details
Product Name:
CM-675 |
CAS No.:
1872466-47-1 |
Purity:
99.67% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | CM-675 |
Description | CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease. |
In vitro | CM-675 (29a) demonstrates a pronounced time-dependent inhibitory effect on class I HDACs, particularly HDAC2. Its potency against HDAC1 also significantly enhances over time, showing increased inhibition (~1 log unit) at varying pre-incubation intervals: 673 nM at 30 minutes, 180 nM at 4 hours, and 69 nM at 6 hours[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 22.5 mg/mL (41.9 mM), Sonication and heating to 60℃ are recommended.
|
Keywords | CM675 | CM-675 | CM 675 |
Inhibitors Related | Valproic acid sodium salt | Panobinostat | Theophylline monohydrate | Sodium 4-phenylbutyrate | Curcumin | Theobromine | Apremilast | Indomethacin | Icariin | 4-Phenylbutyric acid | Theophylline | Doxofylline |
Related Compound Libraries | DNA Damage & Repair Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Chromatin Modification Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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