CLOZAPINE N-OXIDE NEW
| Price | $30 | $45 | $76 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: CLOZAPINE N-OXIDE | CAS No.: 34233-69-7 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | CLOZAPINE N-OXIDE |
| Description | Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist. |
| In vitro | METHODS: hM4Di-transduced primary embryonic rat neuronal cultures were treated with Clozapine N-oxide (0.01-1000 nM), and activity on hM4Di receptors was detected by FLIPR assay. RESULTS: The EC50 value for Clozapine N-oxide was 8.1 nM. [1] METHODS: WT and hM3Dq-transfected mouse embryoma cells ATDC5 were treated with Clozapine N-oxide (750 nM) to detect intracellular calcium signaling. RESULTS: Administration of Clozapine N-oxide resulted in immediate coordinated induction of single [Ca2+]i spines in hM3Dq-ATDC5 cells, and only spontaneous [Ca2+]i signaling was observed in Clozapine N-oxide-treated WT controls. [2] |
| In vivo | METHODS: To investigate potential effects on sleep, Clozapine N-oxide (1-10 mg/kg) was injected intraperitoneally into C57BL/6J mice. RESULTS: Clozapine N-oxide altered sleep in mice. Sleep was analyzed using electroencephalography (EEG) and electromyography (EMG), revealing dose-dependent suppression of rapid eye movement (REM) sleep, changes in EEG spectral power during non-rapid eye movement (NREM) sleep, and alterations in sleep structure. [3] METHODS: To investigate the effects on reward-seeking behavior, Clozapine N-oxide (0.1-10 mg/kg) was administered intraperitoneally to C57BL6/JJcl mice. RESULTS: The off-target effects of commonly used doses of Clozapine N-oxide on motivated reward seeking were negligible. [4] |
| Storage | Powder: -20°C for 3 years | Shipping with blue ice. |
| Solubility Information | Saline : 25 mg/mL (72.92 mM) H2O : 1 mg/mL (2.92 mM), Sonication is recommended. Ethanol : 10 mg/mL DMSO : 60 mg/mL (175.02 mM), The compound is unstable in solution, please use soon. |
| Keywords | Clozapine N-oxide | Dopamine Receptor | BBB | Drug Metabolite | hM3Dq | metabolite | inhibit | Clozapine | G-protein | Muscarinic acetylcholine receptor | mAChR | muscarinic-M4 | CLOZAPINE NOXIDE | CLOZAPINE N-OXIDE | CLOZAPINE N OXIDE | Inhibitor | DREADDs |
| Inhibitors Related | Adiphenine hydrochloride | Alverine citrate | Dapoxetine hydrochloride | Mycophenolate Mofetil | Ribavirin | Octopamine hydrochloride | Adenine | Isonicotinic acid | Choline chloride | Propoxur |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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