Product Name:    Clotrimazole

Synonyms:    myclo;(2-Chlorophenyl)diphenyl-1-imidazolylmethane;(Chlorotrityl)imidazole;1-((2-chlorophenyl)diphenylmethyl)-1h-imidazol;1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole;1-(o-chloro-alpha,alpha-diphenylbenzyl)-imidazol;1-[(2-chlorophenyl)diphenylmethyl]-1h-imidazol;1-(o-Chloro-α,α-diphenylbenzyl)imidazole

CAS:    23593-75-1

MF:    C22H17ClN2

MW:    344.84

EINECS:    245-764-8

Product Categories:    raw material;API;Potassium channel;Aromatics;MYCELEX;Broad-spectrum antifungal drugs;Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;API's;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;23593-75-1

Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane. In mammalian cells, clotrimazole potently inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 μM, respectively).