Closantel NEW
| Price | $34 | $54 | $81 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Closantel | CAS No.: 57808-65-8 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Closantel |
| Description | Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals. |
| In vitro | Closantel (7.5 mg/kg) in combination with a broad-spectrum anthelmintic shows moderate efficacy against caprine Trichostrongylus spp, but is highly effective against Haemonchus contortus. In mice with Fasciola hepatica metacercarial cysts, treatment with closantel (10 mg/kg) leads to extensive peeling on the anterior and posterior extremities, as well as the dorsal and ventral surfaces, resulting in significant overall dermal damage 24 hours post-administration. Furthermore, in sheep infected with resistant H. contortus strains, isotope levels following treatment with radiolabeled closantel are significantly lower compared to susceptible worms. |
| In vivo | Compared to normal conditions, Closantel (50 μg/mL) induces vascular tissue to contract with greater amplitude and higher frequency, reaching a peak muscle tension after approximately 15 minutes, with the amplitude exceeding 1.5 times that of the maximum normal contraction. Additionally, Closantel effectively blocks the infection of host cells by A. phagocytophilum or E. chaffeensis and can clear infections after a one-day treatment in a dose-dependent manner. It also inhibits drug-resistant Enterococcus faecium and Staphylococcus aureus, with minimum inhibitory concentrations (MICs) of 1 μg/mL, and Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 2 μg/mL. Moreover, Closantel inhibits the autophosphorylation activity of three sensor kinases derived from E. chaffeensis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 55 mg/mL (82.95 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | R31520 | halogenated | Inhibitor | Onchocerca | Closantel | OvCHT1 | fromprotozoans | chitinase | O. volvulus | Parasite | inhibit | R 31520 | salicylanilide | chitotriosidase | volvulus |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Doxycycline | Dimethyl sulfoxide |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Antibiotics Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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