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Postion:Product Catalog >CLK8
CLK8
  • CLK8

CLK8 NEW

Price $58
Package 1mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: CLK8 CAS No.: 898920-65-5
Purity: 98.03% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameCLK8
DescriptionCLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-related disorders.
In vitroCLK8 showed no toxicity to U2OS cells with a maximum concentration of 40 μM, maintaining cell viability above 80%. Similarly, CLK8 enhanced the amplitude of Bmal1-d Luc signal in U2OS and NIH 3T3 cells in a dose-dependent manner, and no circadian oscillations were observed in both cell lines[1].
In vivoCLK8 was administered intraperitoneally to mice at a concentration of 25 mg/kg. The results indicated that CLK8 decreased the levels of CLOCK in the whole-cell lysate of mouse liver, while the levels of BMAL1 and CRY1 remained unchanged [1].
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 30 mg/mL (60.12 mM)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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