CL097 hydrochloride NEW
| Price | $1450 | $2190 |
| Package | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: CL097 hydrochloride | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | CL097 hydrochloride |
| Description | CL097 hydrochloride is a potent TLR7 and TLR8 agonist. CL097 hydrochloride induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production [2]. |
| In vitro | CL097 effectively activates NF-κB at concentrations of 0.1 μM in TLR7-transfected HEK293 cells and 4 μM in TLR8-transfected HEK293 cells [1]. It also triggers a hyperactivation of NADPH oxidase in human neutrophils, primarily by promoting phosphorylation of p47phox at specific sites. This activation suggests the involvement of p38 MAPK, ERK1/2, protein kinase C, and Pin1 in regulating the process. Additionally, CL097 not only induces phosphorylation of p47phox on these specific sites but also amplifies fMLF-induced phosphorylation of p47phox [2]. Western blot analysis on neutrophils, with concentrations ranging from 0 to 10 μg/mL and a pretreatment duration of 30 minutes, demonstrated a concentration-dependent increase in p47phox phosphorylation [2]. |
| In vivo | Stimulation with CL097 and a CD40 agonist enhances diabetogenic cytotoxic T lymphocyte (CTL) functionality in NOD mice. When administered subcutaneously (s.c.) at a dosage of 5 mg/kg, CL097 alone elicits a specific target peptide lysis rate of approximately 25%. However, the concurrent administration of CL097 (5 mg/kg, s.c.) and a CD40 agonist (10 mg/kg, intraperitoneally (i.p.)) significantly enhances the specific lysis, doubling the efficacy seen with CL097 alone against IGRP-peptide-coated targets. This study utilized female 8.3 NOD mice aged 5-6 weeks, highlighting a potentiated immune response through combined treatment. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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