Cilengitide NEW
| Price | Get Latest Price | ||
| Package | 1BOX | 10BOX | 100BOX |
| Min. Order: | 1BOX |
| Supply Ability: | 20T |
| Update Time: | 2024-12-23 |
Product Details
| Product Name: Cilengitide | CAS No.: 188968-51-6 |
| Min. Order: 1BOX | Purity: 99% |
| Supply Ability: 20T | Release date: 2024/12/23 |
| Name | Cilengitide |
|---|---|
| Cat. No. | CS-1211 |
| CAS No. | 188968-51-6 |
| MDL. | MFCD04307743 |
| Formula | C27H40N8O7 |
| M. Wt. | 588.66 |
| SMILES | O=C(NCC(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N([C@H]2C(C)C)C)=O)=O)CC(O)=O)=O)[C@H](CCCNC(N)=N)NC2=O |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Application:
Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers[1][2][3].
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- Since: 2020-08-28
- Address: Room 201, Unit 2, Comprehensive Service Building, No.11 Xinxu Impression City, Fengyi Road, Shunhua
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