Chlorprothixene NEW
| Price | $31 | $48 | $98 |
| Package | 100mg | 200mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Chlorprothixene | CAS No.: 113-59-7 |
| Purity: 99.69% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Chlorprothixene |
| Description | Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized. |
| In vitro | When Chlorprothixene acts on the brain, it inhibits the postsynaptic mesolimbic dopamine D1 and D2 receptors, reducing the release of hypothalamic and pituitary hormones. In mouse brains, Chlorprothixene reduces levels of 5HT, NE, and DA. At high doses, Chlorprothixene's effect on adrenal medulla and brain tissue can inhibit the action of nicotinic acid isopropylhydrazine, inducing the release of catecholamines for protective purposes. Additionally, Chlorprothixene has an inhibitory effect on acidic sphingomyelin in murine bronchial epithelial cells, promoting the repair of neuronal myelin concentration, thereby decreasing the incidence of inflammatory responses in mice with cystic fibrosis and also preventing infection by Pseudomonas aeruginosa. |
| In vivo | Chlorprothixene induces Vero 76 cells, resulting in inhibited replication of SARS-CoV. It exhibits high affinity for the murine 5-HT6 receptor in stably transfected HEK-293 cells, with a Ki value of 3 nM, and for the transiently expressed murine 5-HT7 receptor in COS-7 cells, with a Ki value of 5.6 nM. Chlorprothixene has a strong binding affinity to histamine and dopamine receptors including D1, D2, D3, D5, and H1, with Ki values of 18 nM, 2.96 nM, 4.56 nM, 9 nM, and 3.75 nM, respectively. However, its affinity for the H3 receptor is weak, with a Ki value greater than 1000 nM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 10 mg/mL (31.66 mM), Sonication is recommended. Ethanol : 27 mg/mL (85.5 mM) |
| Keywords | Chlorprothixene | Inhibitor | inhibit | Bacterial | Dopamine Receptor | Histamine Receptor |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
| Related Compound Libraries | 神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | FDA 上市藥物庫 | 抗癌上市藥物庫 | GPCR靶點分子庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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