Chloramphenicol NEW
| Price | $40 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Chloramphenicol | CAS No.: 56-75-7 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Chloramphenicol |
| Description | Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Chloramphenicol acts primarily on the 50S subunit of the bacterial 70S ribosome and is active against peptidyltransferases, inhibiting the formation of peptide bonds. |
| In vitro | METHODS: Human lung cancer cells A549 and H1299 were treated with Chloramphenicol (1-100 μg/mL) for 3-24 h. Cell viability was detected by MTT assay. RESULTS: In the 3 h treatment group, the viability of A549 and H1299 cells at 100 μg/mL was 97.0±3.9% and 98.1±5.0%, respectively, and no cytotoxicity was observed. A significant reduction in cell viability was observed in the 24 h treatment group. [1] METHODS: Mouse T cell lines A1.1 and IE5 and human T cell lines Jurkat and Jcam were stimulated with Chloramphenicol (100 nmol/L), and the DNA content was measured by Flow cytometry. RESULTS: Chloramphenicol clearly blocked activation-induced cell death (AICD) in all four cell lines, even though these cells were activated by different stimuli. [2] |
| In vivo | METHODS: To investigate the potential to induce aplastic anemia, Chloramphenicol (2000 mg/kg) and Thiamphenicol (850 mg/kg) were administered by gavage to BALB/c mice once daily for 17 days. RESULTS: Administration of Chloramphenicol and Thiamphenicol at hematotoxic dose levels for 17 days in BALB/c mice was associated with the development of aplastic anemia in humans, inducing reversible anemia but not chronic bone marrow aplasia. [3] |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 1 mg/mL (3.1 mM), Sonication is recommended. Ethanol : 60 mg/mL (185.7 mM) DMSO : 60 mg/mL (185.68 mM) |
| Keywords | Vascular endothelial growth factor receptor | inhibit | Aplastic anaemia | VEGFR | Inhibitor | Atg6 | MMP | Matrix metalloproteinases | JNK | Antibiotic | SENP-1 | A549 | Protein kinase B | HIFs | Akt | PKB | Beclin1 | Bacterial | anaerobic infections | H1299 | Chloramphenicol | Apoptosis | PI-3K | HIF/HIF Prolyl-Hydroxylase | HIF-PH | mitochondria stress | Hypoxia-inducible factors | Autophagy |
| Inhibitors Related | Neomycin sulfate | Kanamycin sulfate | Sulfamethoxazole sodium | Doxycycline | Dimethyl sulfoxide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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