CDK12-IN-E9 NEW
| Price | $193 | $486 | $728 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: CDK12-IN-E9 | CAS No.: 2020052-55-3 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | CDK12-IN-E9 |
| Description | CDK12-IN-E9 is a cell cycle protein kinase (CDK) inhibitor with anticancer and antitumor activity that can be used in the study of breast cancer. |
| In vitro | CDK12-IN-E9 treatment of Kelly, LAN5, SK-N-BE2, PC-9, NCI-H82, and NCI-H3122 cells after 72 hours of action in the concentration range of 10 nM to 10 μM showed significant antiproliferative activity against THZ1R neuroblastoma and lung cancer cells, with IC50 values ranging from 8 to 40 nM. After 6 hours of action in the concentration range of 0 to 3000 nM, CDK12-IN-E9 treatment of Kelly, PC-9, and NCI-H82 cells induced a dose-dependent decrease in phosphorylated and total RNAPII accompanied by a decrease in MYC and MCL1 expression in THZ1R neuroblastoma and lung cancer models. In addition, CDK12-IN-E9 increased PARP cleavage and elevated the proportion of sub-G1 phase cells in THZ1R lung cancer cells, whereas it was more likely to cause G2/M phase block in neuroblastoma cells after 24 hours of exposure. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (230.13 mM), Sonication is recommended. |
| Keywords | CDK12-IN-E9 | CDK-12-IN-E9 | CDK12INE9 | CDK12 IN E9 |
| Inhibitors Related | Ribociclib | Ro-3306 | Rafoxanide | AT7519 | Palbociclib monohydrochloride | CASIN | Palbociclib | GW 441756 | Sodium Oxamate | Abemaciclib | Dinaciclib | Abemaciclib methanesulfonate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $93.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $0.00/1g |
VIP1Y
|
Wuhan Circle Star Chem-medical Technology Co.,Ltd
|
2025-01-17 | |
| $0.00/1kg |
VIP2Y
|
Hubei Changfu Chemical Co., Ltd.
|
2024-12-19 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY