Product Details
Product Name:
CCF0058981 |
CAS No.:
2708934-53-4 |
Purity:
97.31% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | CCF0058981 |
Description | CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-1 3CL pro (SC1) with an IC50 of 19 nM, highlighting its antiviral efficacy and potential in COVID-19 research [1]. |
In vitro | CCF0058981 (CCF981) demonstrates inhibition of cytopathic effect (CPE) and plaque reduction in vitro viral replication, with EC50 values of 497 nM and 558 nM, respectively [1]. Additionally, its 50% cytotoxic concentration (CC50) in the CPE antiviral assay exceeds 50 μM [1]. The compound has a half-life (T1/2) of 21.1 minutes and a clearance rate (CLint) of 141 mL/min/kg in human liver microsomes [1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 1 mg/mL (2.26 mM), Sonication is recommended.
|
Keywords | CCF 0058981 | CCF-0058981 | CCF0058981 |
Inhibitors Related | Nirmatrelvir | EIDD-1931 | Remdesivir | Andrographolide | Silymarin | Umifenovir hydrochloride | Hydroxychloroquine | Ritonavir | Chloroquine phosphate | Chloroquine | Favipiravir | Imatinib |
Related Compound Libraries | Bioactive Compound Library | Anti-Viral Compound Library | Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:1219810-13-5
$89.00 / 1mg
-
-
CAS:798-61-8
$135.00 / 1mg
Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |