Product Details
| Product Name:
CBR-5884 |
CAS No.:
681159-27-3 |
| Purity:
99.97% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| 名稱(chēng) | CBR-5884 |
| 描述 | CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH |
| 體外活性 | CBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits the proliferation of breast cancer lines with high serine synthesis propensity, as well as melanoma. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 47 mg/mL (139.72 mM), Sonication is recommended.
H2O : < 0.1 mg/mL (insoluble)
|
| 關(guān)鍵字 | inhibit | Inhibitor | CBR-5884 | CBR5884 | CBR 5884 |
| 相關(guān)產(chǎn)品 | Disulfiram | Methotrexate | ALDH1A3-IN-3 | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Benzyl alcohol | Isomalt | Isoniazid | Sodium Oxamate | Ivosidenib |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抗乳腺癌化合物庫(kù) | 抗癌細(xì)胞代謝庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 代謝化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) | 抗代謝疾病化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
|
|
$456.00/5mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
|
|
$39.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
United States