Casein Kinase II Inhibitor IV Hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Casein Kinase II Inhibitor IV Hydrochloride | CAS No.: 2320347-54-2 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Casein Kinase II Inhibitor IV Hydrochloride |
| Description | Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation, offering novel therapeutic approaches for treating skin hyperproliferative disorders. |
| In vitro | Treatment with Casein Kinase II Inhibitor IV enhances early differentiation in human epidermal keratinocytes (NHEKs), evidenced by increased keratins 1 and 10 expression at 48 hours. Levels of IVL and TGM also rise at 72 hours and remain elevated at 96 hours. Furthermore, this treatment induces expression of loricrin, a marker of terminal differentiation, at later stages. mRNA expression analysis corroborates these findings, showing early upregulation of keratinocyte differentiation marker genes keratin 1 (5.4-fold) and keratin 10 (5.4-fold) at 12 and 24 hours, while genes marking terminal differentiation, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are significantly increased at 36 and 48 hours. These consistent results underscore Casein Kinase II Inhibitor IV's capacity to drive the differentiation of epidermal progenitor cells into terminally differentiated keratinocytes [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Casein Kinase II Inhibitor IV Hydrochloride | 863598-09-8 free base | 863598-09-8 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $79.00/1mg |
VIP5Y
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TargetMol Chemicals Inc.
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2024-11-19 | |
| $0.00/1kg |
Hebei Jingbo New Material Technology Co., Ltd
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2023-12-25 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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