Capsaicin NEW
| Price | $50 | $75 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Capsaicin | CAS No.: 404-86-4 |
| Purity: 99.41% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Capsaicin |
| Description | Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities. |
| Cell Research | Capsaicin is dissolved in DMSO and stored, and then diluted with appropriate medium before use[3]. FaDu cells are plated at a density of 1×105 cells/well on 24-well plate. After overnight growth, the cells are treated with various concentrations of Capsaicin (0 μM, 50 μM, 100 μM, 150 μM, 200 μM, 250 μM, 300 μM, and 350 μM) for 24, 48 and 72 hours, with medium replacement every 24 hours. At the end of treatment, 30 μL of the tetrazolium compound MTT, and 270 μL of fresh medium are added. After further incubation for 4 hours at 37°C, 200 μL of 0.1 N HCl in 10% SDS is added into each well to dissolve the tetrazolium crystals. Finally, the absorbance at a wavelength of 540 nm is recorded using an ELISA plate reader[3]. |
| In vitro | METHODS: Human pharyngeal squamous carcinoma cells FaDu were treated with Capsaicin (50-300 μM) for 24-72 h. Cell viability was assayed using MTT Assay. RESULTS: As the dose of Capsaicin increased, a decrease in enhanced cell growth was shown. Percentage of viable cells decreased with increase in incubation time. The IC50 value was about 150 μM. [1] METHODS: Human oral epidermoid carcinoma cells KB were treated with Capsaicin (150-250 μM) for 24-48 h. Apoptosis was detected using Hoechst staining. RESULTS: Capsaicin induced apoptosis in KB cells. [2] |
| In vivo | METHODS: To investigate the effects on thermoregulation and locomotor activity, Capsaicin (10-20 mg/kg, saline+3% ethanol+10% Tween 80) was administered by single gavage to C57BL/6J mice with WT and TRPV1 KO. RESULTS: Oral administration of capsaicin resulted in a long-term increase in TRPV1-dependent acute hypothermia and TRPV1-independent locomotor activity, in addition to activation of brain circuits controlling thermoregulation and metabolism. [3] METHODS: To assay neuroprotective activity, Capsaicin (5-20 mg/kg) was administered orally to mice given scopolamine once daily for seven days. RESULTS: Capsaicin exerted empirical neuroprotective effects through restoration of mitochondrial function, antioxidant effects and modulation of pro-inflammatory cytokines. A 10 mg/kg dose of Capsaicin for seven consecutive days was the most effective dose. [4] |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (163.71 mM) 10% DMSO+90% Saline : 1.53 mg/mL (5.01 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| Keywords | Capsaicin |
| Inhibitors Related | Stavudine | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Valproic Acid | Paeonol | Naringin | Gefitinib | Oleic acid |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Flavor Compound Library | Alkaloid Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Neuroprotective Compound Library | Anti-Cancer Approved Drug Library | Cosmetic Ingredient Compound Library | Gut Microbial Metabolite Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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