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Calpeptin NEW

Price	$30	$44	$61
Package	2mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: Calpeptin	CAS No.: 117591-20-5
Purity: 98.33%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	Calpeptin
Description	Calpeptin is a potent, cell-permeable calpain inhibitor.
In vitro	Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. [1] In differentiating PC12 cells, Calpeptin promotes neurite elongation via inhibition of Calpain activity. [2] In rat retinal ganglion cells, Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential, and thus provides functional neuroprotection. [3]
In vivo	In a feline right ventricular (RV) PO (RVPO) model, calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3, cleavage of their substrates, and cardiomyocyte programmed cell death. [4] In a rat focal cerebral ischemia–reperfusion injury model, Calpeptin reduces the neuronal apoptosis in hippocampal CA1 sector via inhibition of the expression of Caspase-3. [5]
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 67 mg/mL (184.8 mM) DMSO : 80 mg/mL (220.71 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble)
Keywords	Cathepsin \| Apoptosis \| inhibit \| Inhibitor \| Proteasome \| Calpeptin
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Acetylcysteine \| Kaempferol \| Myricetin \| Sodium 4-phenylbutyrate \| L-Ascorbic acid \| Dextran sulfate sodium salt (MW 4500-5500) \| Metronidazole \| Sorafenib \| Tributyrin \| Lidocaine hydrochloride
Related Compound Libraries	Apoptosis Compound Library \| Bioactive Compound Library \| Ubiquitination Compound Library \| HIF-1 Signaling Pathway Compound Library \| Inhibitor Library \| Anti-Cardiovascular Disease Compound Library \| Bioactive Compounds Library Max \| Covalent Inhibitor Library \| Preclinical Compound Library \| Anti-COVID-19 Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.