Calcipotriol NEW
| Price | $52 | $72 | $133 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Calcipotriol | CAS No.: 112965-21-6 |
| Purity: 99.07% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Calcipotriol |
| Description | Calcipotriol (MC 903) is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor. |
| In vitro | Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM), when NHEK cells are not stimulated with IL-17A or IL-22. The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20, and 40 nM in a dose-dependent manner [1]. Treatment of natural killer (NK) cells with drugs modulate their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)2D3, Calcipotriol or FTY720 for 4 h. All three concentrations of Calcipotriol, 1,25(OH)2D3, and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation [2]. |
| In vivo | Compare with placebo, the weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002). Survival is equally distributed between the groups. One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived [3]. |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (242.37 mM) Ethanol : 50 mg/mL (121.18 mM), Sonication is recommended. |
| Keywords | Vitamin D receptor | inhibit | MC-903 | VD/VDR | Vitamin D | Calcipotriol | Inhibitor | MC903 |
| Inhibitors Related | Impurity C of Calcitriol | Acenocoumarol | Ercalcidiol | Calcitriol Impurities D | Retinyl acetate | DL-Panthenol | Maxacalcitol | Ercalcitriol | 5,6-trans-Vitamin D3 | Biotin | Calcipotriol monohydrate | 24, 25-Dihydroxy VD2 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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