CAIX Inhibitor S4 NEW
| Price | $34 | $55 | $97 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: CAIX Inhibitor S4 | CAS No.: 1330061-67-0 |
| Purity: 98.35% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | CAIX Inhibitor S4 |
| Description | CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM. |
| In vitro | CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia. CAIX Inhibitor S4 (1, 10, 100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner with IC50s of 481 μM, >1000 μM, and 20 μM, respectively. CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration-dependent manner[1]. |
| In vivo | CAIX Inhibitor S4 (10 mg/kg; i.p.) reduces lung metastasis in the orthotopic MDA-MB-231 mouse model without impacting primary tumor growth[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 245 mg/mL (730.51 mM), Sonication is recommended. |
| Keywords | CAIX Inhibitor S 4 | lung | CAIX Inhibitor S-4 | metastasis | S-4 | XII | orthotopic | Carbonate dehydratase | Inhibitor | inhibit | Carbonic Anhydrase | S 4 | tumor | CAIX Inhibitor S4 |
| Inhibitors Related | Benzenesulfonamide | Urea | Topiramate | Cyclamic acid sodium | Ellagic acid | Orthanilamide | Tioxolone | Zonisamide | Histone acetyltransferase p300 Inhibitor 4c | EMAC10101d | pNNP | Trichlormethiazide |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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