BW 245C NEW
| Price | $199 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: BW 245C | CAS No.: 72814-32-5 |
| Purity: ≥99% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | BW 245C |
| Description | BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke. |
| In vitro | The prostaglandin DP receptor agonist BW 245C (0.01-1μM) inhibited TGF-β-induced collagen secretion and increased intracellular cAMP in lung fibroblasts [3]. The use of the DP receptor agonist BW 245C (0.1-3μmol/L) dose-dependently increased the transendothelial resistance of human umbilical vein endothelial cells and decreased FITC-dextran permeability. Moreover, it elevated intracellular cAMP levels and subsequent protein kinase A (PKA) activity [4]. |
| In vivo | Injection of the DP1 agonist BW 245C (100 nM, 20 uL) did not significantly increase MBP-positive eosinophils in the esophageal epithelial cells of OVA-sensitized guinea pigs [2]. WT and DP1 (-/-) mice underwent middle cerebral artery occlusion, followed by a single intraperitoneal injection of vehicle or 0.02, 0.2, or 2.0 mg/kg BW 245C, and then immediate reperfusion. The results showed that BW 245C treatment significantly increased baseline CBF in WT mice but not in DP1 (-/-) mice [1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (81.42 mM), Sonication is recommended. |
| Keywords | BW 245C |
| Inhibitors Related | Angoroside C | Pranoprofen | Tranilast | Rutin | Ozagrel | Ethamsylate | Rebamipide | Evodiamine | Tebufelone | p-Hydroxycinnamic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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