BMS-564929 NEW
| Price | $1980 | $2800 |
| Package | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-08 |
Product Details
| Product Name: BMS-564929 | CAS No.: 627530-84-1 |
| Supply Ability: 10g | Release date: 2024/11/08 |
Product Introduction
Bioactivity
| 名稱 | BMS-564929 |
| 描述 | BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM). |
| 體外活性 | BMS-564929 exhibits high selectivity, being over 1000-fold more selective for androgen receptors (AR) compared to estrogen receptors (ER) α and β, glucocorticoid receptor (GR), and mineralocorticoid receptor (MR), with about 400-fold selectivity against progesterone receptor (PR). It demonstrates no measurable activity in functional transactivation assays involving ERα/β, GR, MR, or PR at concentrations up to 30 μM. Furthermore, BMS-564929 shows potent activity in the C2C12 myoblast cell line, with an EC50 (the concentration needed to achieve 50% of the maximum stimulatory effect of DHT) of 0.44±0.03 nM, and in the PEC cell line, the EC50 is 8.66±0.22 nM. |
| 體內活性 | BMS-564929 demonstrates a significant enhancement in muscle stimulation potency, being over 200 times more effective than T propionate (TP) and 80 times more selective in targeting muscle versus prostate in the evaluated model[1]. Administered orally, BMS-564929 showcases superior efficacy in the levator ani muscle, with an ED50 of 0.0009 mg/kg, compared to its ED50 of 0.14 mg/kg in the prostate, indicating a notable 160-fold preference for muscle over prostate in sexually mature, castrated male rats—a thoroughly studied animal model. Remarkably, muscle stimulation peaks at approximately 100% with a dose of 0.1 mg/kg and exceeds 125% at higher doses of 0.3 and 1 mg/kg. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (163.55 mM), Sonication is recommended. |
| 關鍵字 | BMS-564929 | BMS564929 | BMS 564929 |
| 相關產品 | Dehydroisoandrosterone 3-acetate | Bicalutamide | 2,2,5,7,8-Pentamethyl-6-Chromanol | S-23 | Bavdegalutamide | Octinoxate | Adrenosterone | Allura Red AC | SK33 | Sunset Yellow FCF | Ostarine | Flutamide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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