Bisindolylmaleimide VIII NEW
| Price | $293 | $722 | $987 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-20 |
Product Details
| Product Name: Bisindolylmaleimide VIII | CAS No.: 125313-65-7 |
| Purity: 98.01% | Supply Ability: 10g |
| Release date: 2024/11/20 |
Product Introduction
Bioactivity
| Name | Bisindolylmaleimide VIII |
| Description | Bisindolylmaleimide VIII (Ro-31-7549) is a selective and potent protein kinase C (PKC) inhibitor with good inhibition of PKC-α, PKC-β I, PKC-β II, PKC-γ, and PKC-ε.Bisindolylmaleimide VIII Bisindolylmaleimide VIII inhibits T cell-mediated autoimmune diseases and enhances Fas-mediated apoptosis through a protein kinase C-independent mechanism. |
| In vitro | Ro-31-7549 (5 μM; 8, 12h; 1321N1 cells) significantly increases TRA-8-induced cell death in a time- and dose-dependent manner.[2] After combined treatment with Ro-31-7549 (5 μM; 6h; 1321N1 cells) and TRA-8, procaspase-8 was significantly reduced at 4 h and completely disappeared at 6h.[2] |
| In vivo | Ro-31-7549 (100 μg; i.p.; every other day for three doses; 6-8-week-old female NOD/SCID mice) combined with toTRA-8, resulted in nearly complete tumor regression. Bisindolylmaleimide VIII alone did not result in significant tumor regression.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Vortex | Ro-31-7549 | UNII-FC61260G4Q | Ro-31-7549 Monohydrate |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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