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Postion:Product Catalog >BI8622
BI8622
  • BI8622

BI8622 NEW

Price $116 $297 $987
Package 1mg 5mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: BI8622 CAS No.: 1875036-74-0
Purity: 98.28% Supply Ability: 10g
Release date: 2024/11/07

Product Introduction

Bioactivity

名稱BI8622
描述BI8622 is a ubiquitin ligase HUWE1-specific antagonist that restores the level of RP2 mutants in retinal cell lines and inhibits the activation of NLRP3, NLRC4, and AIM2 inflammatory vesicles in cells.
體外活性BI8622 is a specific inhibitor of HUWE1 ubiquitin ligase with an IC50 of 3.1 μM.It inhibited ubiquitination of MCL1 in HeLa cells by ectopic expression of HUWE1, with an IC50 value of 6.8 μM.In addition, BI8622 inhibited clonogenic formation of Ls174T cells with an estimated IC50 of 8.4 μM. BI8622 (10 μM, 1-4 days treatment) delayed the progression of Ls174T cells at all stages of the cell cycle, with the most pronounced inhibitory effect in the G1 phase.BI8622 (0-50 μM, 16 hours treatment) prevented the degradation of MCL1 in HeLa cells under UV irradiation by inhibiting HUWE1. It also inhibited MYC-dependent transcriptional activation in colorectal cancer cells. [1]
存儲條件keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL (234.46 mM), Sonication is recommended.
關鍵字BI-8622 | BI8622
相關產(chǎn)品Pemetrexed | Methotrexate | 5-Fluorouracil | Procaine | Remdesivir | Ribavirin | Trimethoprim | N-Nitrosodiethylamine | Hydroxyurea | Acyclovir | Oxolinic acid | Temozolomide

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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