Berberine hydrochloride, also known as berberine hydrochloride, has been used in clinical practice for a long time as a heat-clearing detoxification and antibacterial drug. It is often used in the treatment of dysentery, acute gastroenteritis, chronic cholecystitis, conjunctivitis, suppurative otitis media and other diseases, and has significant curative effect. Berberine hydrochloride is an isoquinoline alkaloid, which exists in many plants of 4 families and 10 genera, such as Berberine family. Yellow acicular crystals of berberine can be precipitated from ether. Berberine is a quaternary ammonium alkaloid, and its salts have a relatively small solubility in water, such as 1∶500 for hydrochloride and 1∶30 for sulfate.

Antibacterial action

Berberine has antibacterial effect on hemolytic streptococcus, Staphylococcus aureus, gonorrhoeae, Fredricki and Shigella dysenteriae, and can enhance white blood cell phagocytosis. Berberine hydrochloride (commonly known as berberine hydrochloride) has been widely used in the treatment of gastroenteritis, bacillary dysentery, tuberculosis, scarlet fever, acute tonsillitis and respiratory infection also has a certain effect.

Pharmacological action

The antibacterial spectrum is wide, and it has antibacterial effect on many kinds of gram-positive and gram-negative bacteria in vitro, including hemolytic streptococcus, Staphylococcus aureus and Vibrio cholerae. Meningococcus, Shigella dysentery, typhoid bacillus, diphtheria bacillus have strong inhibitory effect, low concentration of bacteriostasis, high concentration of bactericidal. It also has certain inhibitory effect on influenza virus, amoeba, leptospira and some skin fungi. In vitro experiments show that berberine can enhance the phagocytosis of leukocyte and hepatic reticuloendothelial system. Dysentery bacillus, hemolytic streptococcus, staphylococcus aureus and so on are easy to develop resistance to this product. There is no cross-resistance between this product and penicillin, streptomycin, etc.