Benzocaine NEW
| Price | $29 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Benzocaine | CAS No.: 94-09-7 |
| Purity: 99.97% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Benzocaine |
| Description | Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
| In vitro | Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent manner, with an IC50 of 0.8 mM in HEK293T cells. At 1 mM, Benzocaine inhibits approximately 55% of wild-type Na+ current, about 95% of μ1-N1584A mutant current, and about 80% of μ1-I1575A mutant current. [1] Benzocaine produces a biphasic (protective/inductive) concentration-dependent hemolytic effect on rat erythrocytes, with effective Benzocaine:lipid molar ratios in the membrane for protection (RePROT), onset of hemolysis (ReSAT), and 100% membrane solubilization (ReSOL) at 1.0:1, 1.1:1, and 1.3:1, respectively. [2] During repetitive pulses, Benzocaine and 4-hydroxybenzoate interact with the open and inactivated channels, but the complex dissociates too rapidly during interpulse to achieve a significant use-dependent Na+ current block. [3] Benzocaine (500 μM) reduces peak and steady-state currents and increases the amplitude of the inactivating component from 21.7% to 30.2% (n=7, P<0.05), resulting in an average block of 30.9% at the end of pulses to +60 mV (n=7). It also significantly accelerates the initial phase of deactivation (τf=27.2±2.6 ms, n=7, P<0.01) without affecting the slow phase of tail current decline. Benzocaine binds with high affinity to an intracellular site producing 'agonist' effects and a low-affinity subsite in the inner mouth producing blocking effects. Benzocaine and extracellular K(+) interact to alter the voltage-dependence of channel opening. [4] |
| In vivo | Benzocaine is absorbed rapidly and similarly through both viable and nonviable skin of the hairless guinea pig, the absorption of the two acidic compounds, benzoic acid and PABA, is greater through nonviable skin. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (302.68 mM) Ethanol : 31 mg/mL (187.7 mM) |
| Keywords | Na channels | 34584 | Na+ channels | Inhibitor | inhibit | Sodium Channel | Benzocaine |
| Inhibitors Related | Phenytoin sodium | Procaine | Lidocaine Hydrochloride hydrate | Lidocaine | Safinamide | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Cholesterol | Amitriptyline hydrochloride | Riluzole | Flurbiprofen |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $160.00/1kg |
VIP1Y
|
Guangdong Junhua Chemical Co., Ltd
|
2024-12-18 | |
| $29.00/1mL |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
| $0.00/25kg |
VIP1Y
|
Hebei Mojin Biotechnology Co.,Ltd
|
2024-09-25 | |
| $20.00/1kg |
VIP1Y
|
Shaanxi Franta Biotechnology Co., Ltd
|
2024-09-23 | |
| $20.00/1kg |
VIP3Y
|
Hebei Dangtong Import and export Co LTD
|
2024-09-11 | |
| $0.00/1KG |
VIP6Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2024-08-13 | |
| $1.00/1kg |
VIP2Y
|
Jinan Million Pharmaceutical Co., Ltd
|
2024-07-24 | |
| $10.00/1kg |
VIP1Y
|
Hebei Ganmiao New material Technology Co., LTD
|
2024-06-07 | |
| $10.00/1kg |
Nanjing Deda New Material Technology Ltd.
|
2024-06-04 | ||
| $1.00/1g |
VIP1Y
|
Apeloa production Co.,Limited
|
2024-05-24 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY