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Postion:Product Catalog >BAY1082439
BAY1082439
  • BAY1082439

BAY1082439 NEW

Price $31 $44 $72
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: BAY1082439 CAS No.: 1375469-38-7
Purity: 100% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameBAY1082439
DescriptionBAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2]. Additionally, BAY1082439 is effective against mutated forms of PIK3CA.
In vitroBAY1082439 is a highly selective PI3Kα/α-balanced inhibitor. BAY1082439 (0.1-1 μM; 72 hours) is more effective than PI3Kα- and/or PI3Kβ-selective inhibitors in blocking PTEN-null prostate cancer cells[2]. BAY1082439 exhibits an IC50 ratio of 1:3 in biochemical assays of PI3Kα (4.9 nM) vs. PI3Kα (15.0 nM) and shows >1000-fold selectivity against mTOR kinase[1].
In vivoBAY1082439 (75 mg/kg; p.o.; daily for 4 weeks) effectively prevents the progression of Pten-null prostate cancer[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : Slightly soluble
KeywordsPTEN | BAY 1082439 | inhibit | cancer | oral | Inhibitor | BAY-1082439 | forms | Phosphoinositide 3-kinase | PI3K | Apoptosis | BAY1082439 | mutated | PIK3CA | prostate
Inhibitors RelatedStavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride
Related Compound LibrariesGlycometabolism Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name Price   Suppliers Update time
$31.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-19
$1.00/1KG
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Career Henan Chemical Co
2019-12-25
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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