天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >BAY-293
BAY-293
  • BAY-293

BAY-293 NEW

Price $48 $113 $197
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: BAY-293 CAS No.: 2244904-70-7
Purity: 96.8% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameBAY-293
DescriptionBAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
In vitroBAY-293 is a SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM and displays no significant activity against KRAS WT-CRAF RBD, CDC42 and EGFR (>20 uM). It inhibits the activation of RAS in HeLa cells with IC50 of 410 nM, efficiently inhibits pERK levels in K562 cells after incubation for 60 min without affecting total protein levels of ERK (IC50: 180 nM). BAY-293 shows antiproliferative activity against wild-type KRAS cell lines (K562, MOLM-13; IC50~1 uM) and cell lines with KRASG12C mutation (NCI-H358, Calu-; IC50~3 uM) by preventing the formation of the KRAS-SOS1 complex.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 110 mg/mL (245.22 mM)
KeywordsInhibitor | BAY 293 | inhibit | Ras | BAY293 | BAY-293
Inhibitors RelatedRegorafenib monohydrate | Sorafenib | Ketoconazole | MRTX1133 | Salirasib | RMC-6236 | Regorafenib | Dabrafenib | Sorafenib tosylate | PLX-4720 | CASIN | Sotorasib
Related Compound LibrariesFerroptosis Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | Bioactive Compounds Library Max | GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$1520.00/25mg
VIP1Y
TargetMol Chemicals Inc.
2024-10-22
$82.00/2mg
VIP3Y
TargetMol Chemicals Inc.
2024-10-23
$17.00/1g
VIP5Y
Career Henan Chemica Co
2020-10-28
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
INQUIRY