BAY 2416964 NEW
| Price | $40 | $77 | $123 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: BAY 2416964 | CAS No.: 2242464-44-2 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | BAY 2416964 |
| Description | BAY 2416964 is a small molecule inhibitor that selectively targets aromatic receptor (AhR) with an IC50 of 341 nM and is commonly used in cancer immunotherapy research. |
| In vitro | METHODS: Human monocytes were treated with BAY 2416964 (1 nM-10 μM), kynurenic acid (200 μM), and LPS (10 ng/mL) for 24 h, and TNF-α levels were measured by ELISA. RESULTS: kynurenic acid-induced AhR activation inhibited TNF-α production in LPS-stimulated monocytes, and BAY 2416964 dose-dependently rescued this AhR-mediated inhibition. [1] |
| In vivo | METHODS: To assay antitumor activity in vivo, BAY 2416964 (30 mg/kg) was administered orally to NSG mice bearing B16F10-OVA tumors once daily for seven days. RESULTS: BAY 2416964 inhibited tumor growth.BAY 2416964 increased the frequency of immunostimulatory tumor-infiltrating CD8+ T cells and N cells, and decreased the frequency of immunosuppressive GR1-positive myeloid cells and CD206+M2 macrophages. [1] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (644.63 mM), Sonication is recommended. |
| Keywords | inhibit | Aryl Hydrocarbon Receptor | CYP1A1 | Inhibitor | AhR | anti-cancer | BAY-2416964 | BAY 2416964 | BAY2416964 |
| Inhibitors Related | Carbidopa monohydrate | Diosmin | AHR antagonist 2 | SGA360 | Benzyl butyl phthalate | Skatole | Carbidopa | L-Kynurenine | Indole-3-carbinol | MeBIO | StemRegenin 1 | PD98059 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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