Product Details
Product Name:
B355252 |
CAS No.:
1261576-81-1 |
Purity:
99.92% |
Supply Ability:
10g |
Release date:
2024/11/12 |
Product Introduction
Bioactivity
名稱 | B355252 |
描述 | B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth. |
體外活性 | Method: HT22 cells were pretreated for 2 hours with various concentrations of B355252 (0.625-20 μM). This was followed by the addition of 300 μM CoCl2 and incubation at 37oC for 24 hours. At the end of this time, cell viability was determined by resazurin assay as described below. Result: From 0.625 to 5 μM, B355252 increased cell viability in a dose-dependent manner, protecting against CoCl2-induced hypoxia. Above 5 μM, B355252 became toxic to the cells and, synergistically with CoCl2, decreased cell viability. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 25 mg/mL (48.63 mM)
|
關(guān)鍵字 | neurite outgrowth | ischemic neurons | HT22 | glutamate | Inhibitor | Apoptosis | DNA damage | inhibit | NGF | LDH level | ROS production | B 355252 | Parkinson disease | phenoxy thiophene sulfonamide | B-355252 | B355252 |
相關(guān)庫 | 經(jīng)典已知活性庫 | 神經(jīng)保護化合物庫 | NO PAINS 化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
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$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |