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Azadiradione NEW

Price	$133	$302	$543
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: Azadiradione	CAS No.: 26241-51-0
Purity: 99.52%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	Azadiradione
Description	Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica
In vitro	Azadiradione (AZD)?ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent.?All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes.?Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function.?Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity.?These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 55 mg/ml (122.07 mM)
Keywords	anti-nociceptive \| antimycobacterial \| Inhibitor \| Heat shock proteins \| inhibit \| HSF1 Activator \| Azadiradione \| HSP \| anti-inflammatory activities \| bioactive limonoid
Related Compound Libraries	Bioactive Compound Library \| Selected Plant-Sourced Compound Library \| Natural Product Library \| NO PAINS Compound Library \| Natural Product Library for HTS \| RO5 Drug-like Natural Product Library \| Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.