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Postion:Product Catalog >AZ32
AZ32
  • AZ32

AZ32 NEW

Price $51 $74 $122
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: AZ32 CAS No.: 2288709-96-4
Purity: 99.94% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameAZ32
DescriptionAZ32 is an orally bioavailable, blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for the ATM enzyme and an IC50 of 0.31 μM for ATM in cells.
In vitroAZ32 is an enhanced blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro[1].
In vivoAZ32 exhibits superior blood-brain barrier (BBB) penetration and is more effective as a radiosensitizer in both syngeneic and human orthotopic mouse glioma models compared to AZ31. It acts as a specific inhibitor of the ATM kinase, showcasing commendable BBB penetration in mice. A single oral dose of AZ32 (200 mg/kg) maintains free-brain concentrations above the cellular IC50 for around 22 hours [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 55 mg/mL (167.49 mM)
KeywordsAtaxia telangiectasia mutated | ATM and RAD3 related | inhibit | Inhibitor | AZ 32 | AZ32 | ATM/ATR | AZ-32
Inhibitors RelatedCP-466722 | Ro 90-7501 | AZ31 | Dactolisib | Berzosertib | Elimusertib | GJ103 sodium salt | KU60019 | Ceralasertib | (Z)-Mirin | NU6027 | Schisandrin B
Related Compound LibrariesPI3K-AKT-mTOR Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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