Avibactam sodium hydrate NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-20 |
Product Details
| Product Name: Avibactam sodium hydrate | CAS No.: 2938989-90-1 |
| Purity: 99.95% | Supply Ability: 10g |
| Release date: 2025/05/20 |
Product Introduction
Bioactivity
| Name | Avibactam sodium hydrate |
| Description | Avibactam sodium hydrate (NXL-104 hydrate) is a highly effective β-lactamase inhibitor that inhibits β-lactamases TEM-1 and CTX-M-15, as well as the carbapenemase produced by Klebsiella pneumoniae and carbapenem-resistant Enterobacteriaceae. |
| In vitro | Avibactam sodium hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor with IC50 values of 8 nM and 5 nM for the β-lactamases TEM-1 and CTX-M-15, respectively.[1] Although Avibactam sodium hydrate has little or no antimicrobial activity, it effectively inhibits class A and C β-lactamases, and has no significant effect on the activities of metallo-β-lactamases and Fusobacterium oxysporum OXA carbapenemase. [2] When Avibactam sodium hydrate was used in combination with ceftazidime (concentration range 0-256 mg/L), it inhibited the growth of 16 blaKPC-2-positive and 1 blaOXA-232-positive strains of K. pneumoniae with MIC50 and MIC90 of 8 mg/L.[4] |
| In vivo | In a mouse model infected with K. pneumoniae Y8 strain, Avibactam sodium hydrate in combination with ceftazidime (0.375 mg/g; subcutaneous injection; every 8 hours for 10 days) significantly inhibited bacterial growth and demonstrated some therapeutic effect. [3] After a single subcutaneous injection of Avibactam sodium hydrate (64 mg/kg), its estimated mean terminal half-life against Pseudomonas aeruginosa infection in a neutropenic mouse lung infection model was 0.24 hours. [3] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 150 mg/mL (491.42 mM), Sonication is recommended. |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Chitosan (MW 150000) | Ampicillin sodium | Doxycycline (hyclate) | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Dimethyl sulfoxide | Crystal Violet |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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