Autophagy-IN-2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Autophagy-IN-2 | CAS No.: 2755454-90-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Autophagy-IN-2 |
| Description | Autophagy-IN-2 (Compound 7h) is an autophagic flux inhibitor that induces cancer cell apoptosis, making it a valuable agent for triple-negative breast cancer research [1]. |
| In vitro | Autophagy-IN-2 (Compound 7h), across a concentration range of 0-200 μM for 48 hours, exhibits anti-viability effects on various cancer cell lines, as evidenced by its IC 50 values across a panel including MDA-MB-231, MDA-MB-468, and others. At lower concentrations (0-20 μM) and varying time points up to 48 hours, this compound disrupts autophagic flux and DNA repair mechanisms by decreasing chromatin ubiquitination, linked to a p62-dependent process. Additionally, Autophagy-IN-2 triggers cell cycle arrest in the S-phase and initiates mitochondrial-dependent intrinsic apoptosis. Western blot analysis reveals a dose and time-dependent increase in LC3B-II, p62 accumulation, and DNA damage markers in treated TNBC cells, alongside modifications in cell cycle and apoptosis-related proteins. Cell cycle and apoptosis assays further confirm the compound's ability to induce S-phase arrest and significantly enhance apoptosis, particularly late-phase, in a dose-dependent manner in TNBC cells. |
| In vivo | Autophagy-IN-2 (Compound 7h), administered intraperitoneally (i.p.) at 5 and 15 mg/kg every three days for three weeks, dose-dependently suppressed tumor growth in six-week-old female NOD/SCID mice with MDA-MB-231 xenografts. This treatment inhibited human TNBC tumor growth and increased the expression of LC3B-II, p62, γH2AX, and PARP in a concentration-dependent manner. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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