Product Details
| Product Name:
Atogepant |
CAS No.:
1374248-81-3 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Atogepant |
| Description | Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine. |
| In vitro | Atogepant has a CGRP IC50=0.026 nM for human clones.
The binding affinities of Atogepant for human and non-human CGRP receptors were: human (cloned) Ki=0.015 nM, human (natural) Ki=0.026 nM, rhesus macaque Ki=0.009 nM, rat Ki=0.7 nM, mouse Ki=0.13 nM, rabbit Ki=2.1 nM, dog Ki=1.2 nM, respectively. [1][2] |
| In vivo | Oral administration of Atogepant to rats (at doses of 3, 10, and 30 mg/kg, respectively) once daily for 9 days showed that Atogepant effectively attenuated the abnormal facial pain induced by nitroglycerin and ameliorated the capsaicin-induced vasodilation of primate dermis in rats.[2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL (132.56 mM), Sonication is recommended.
|
| Keywords | MK8031 | Atogepant |
| Inhibitors Related | HCGRP-(8-37) acetate | Olcegepant | Ubrogepant | Rimegepant | Vazegepant hydrochloride | Vazegepant | CGRP 8-37 (rat) | β-CGRP, human acetate | Calcitonin（salmon） Acetate(47931-85-1(free base)) | Galcanezumab | Calcitonin (salmon) | CGRP antagonist 1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1g |
VIP2Y
|
shandong perfect biotechnology co.ltd
|
2023-08-02 |
United States