Product Details
| Product Name:
Ascrinvacumab |
CAS No.:
1463459-96-2 |
| Purity:
98.18% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱(chēng) | Ascrinvacumab |
| 描述 | Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1 with a Kd value of 7 nM for human ALK1. It has an inhibitory effect on TGF-β and can be used to study hepatocellular carcinoma (HCC). |
| 體外活性 | Ascrinvacumab binds to human ALK1 with a Kd value of 7 nM[1].
In a 30-minute treatment, Ascrinvacumab blocks the response induced by BMP9 and FCS, alleviating BMP9-induced Smad1 phosphorylation intensity and duration[1].
At concentrations ranging from 0.01 to 10 μg/mL for 2 hours, Ascrinvacumab inhibits the binding of BMP9 to ALK1[1].
At 40 μg/mL for 2 hours, Ascrinvacumab effectively inhibits endothelial sprouting in human umbilical vein endothelial cells (HUVECs)[1]. |
| 體內(nèi)活性 | In a mouse xenograft tumor model, the combination of Ascrinvacumab with bevacizumab (anti-VEGF) reduces human vascular density and enhances the anti-tumor efficacy[1]. |
| 存儲(chǔ)條件 | store at low temperature | store at -80°C | Shipping with blue ice. |
| 關(guān)鍵字 | PF03446962 | PF 03446962 | Ascrinvacumab |
| 相關(guān)產(chǎn)品 | Monocrotaline | DMH-1 | Hydrochlorothiazide | Crizotinib | Chromenone 1 | LY-364947 | Ceritinib | BMP signaling agonist sb4 | Pirfenidone | A 83-01 | Galunisertib | Alantolactone |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States