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Postion:Product Catalog >ARV-471
ARV-471
  • ARV-471

ARV-471 NEW

Price $265 $657 $935
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: ARV-471 CAS No.: 2229711-68-4
Purity: 99.85% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameARV-471
DescriptionVepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
In vitroVepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM.
In vivoVepdegestrant (ARV-471) (3, 10, and 30 mpk/day, orally) demonstrated significant antitumor activity in estradiol-dependent MCF7 xenografts, with a greater than 90% reduction in ER protein; even more significant tumor growth inhibition (131% TGI) was observed in the MCF7 xenograft model, with a significant reduction in ER protein levels when combined with the CDK4/6 inhibitor palbociclib.[1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 100 mg/mL (138.14 mM), Sonication is recommended.
Keywordsoral | Inhibitor | breast cancer | PROTAC | E3 ligase | inhibit | hetero-bifunctional | ARV 471 | ubiquitylation | PROTACs | Estrogen Receptor/ERR | ARV471 | estrogen receptor | proteasome | ARV-471
Inhibitors RelatedKaempferol | Tamoxifen | Estradiol | Estradiol benzoate | Genistin | Cholesterol | Estriol | Chrysin | Ethisterone | Estrone
Related Compound LibrariesBioactive Compound Library | Drug Repurposing Compound Library | Endocrinology-Hormone Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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