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Postion:Product Catalog >ARS-853
ARS-853
  • ARS-853

ARS-853 NEW

Price $153 $392 $583
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: ARS-853 CAS No.: 1629268-00-3
Purity: 97.43% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameARS-853
DescriptionARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
In vitroARS-853 decreases phosphorylation of c-RAF, ERK, and Akt. ARS853 inhibits proliferation of six lung cancer cell lines containing the K-RASG12C mutation, including H358 cells (IC50 = 2.5 μM), but does not inhibit proliferation of PC-9 cells, which contain wild-type K-RAS[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 5.5 mg/mL (12.7 mM), Sonication is recommended.
KeywordsKRAS | Apoptosis | ARS-853 | cancer | mutant | state | inhibit | Inhibitor | ARS853 | inactive | Ras | selective,covalent | G12C | ARS 853
Inhibitors RelatedStavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride
Related Compound LibrariesHighly Selective Inhibitor Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Amikon Limited
2018-06-08
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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