Product Details
| Product Name:
ARN5187 |
CAS No.:
1287451-26-6 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | ARN5187 |
| Description | ARN5187 is a lysosomal compound, REV-ERB β Ligand. ARN5187 inhibits REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomal efficacy and cytotoxicity, and can induce apoptosis. |
| In vitro | ARN5187 (compound 1) (0-100 μM; 48 h) demonstrates cytotoxicity with an EC50 of 23.5 μM in BT-474 cells and IC50 values of 30.14 μM and >100 μM in BT-474 and HMEC cells, respectively [1][2]. In HEK-293 cells, ARN5187 (0-100 μM) activates the RevRE reporter in a concentration-dependent manner [1]. ARN5187 (25, 50 μM) exhibits lysosomotropic-independent REV-ERB antagonistic activity [1], and at 50 μM (24 h), it shows autophagy inhibition and affects autophagy formation and maturation [1]. In BT-474 cells, ARN5187 significantly enhances the expression of BMAL1, PER1, and PEPCK in a dose-dependent manner (25, 50 μM), and at 50 μM (24 h), significantly increases the expression of α-LC3-II, α-p62, and α-Cleaved PARP [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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