Product Details
| Product Name:
Apicidin |
CAS No.:
183506-66-3 |
| Purity:
99.68% |
Supply Ability:
10g |
| Release date:
2025/06/17 |
Product Introduction
Bioactivity
| Name | Apicidin |
| Description | Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic and antiproliferative activity. It attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, making it a valuable tool for leukemia research. |
| In vitro | Apicidin (0.1-10 μM, 24 h) inhibits the viability of AT-84 cells in a dose-dependent manner, with concentrations ≥1 μM leading to a significant decrease in viability[1]. |
| In vivo | In the mouse tumor model, at the end of 14 days, Apicidin (5 mg/kg, intraperitoneal injection, once daily) significantly inhibited tumor growth by up to 46% compared to the control group[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10 mg/mL (16.03 mM), Sonication is recommended.
|
| Keywords | OSI-2040 | OSI2040 | HDAC | Autophagy | Apoptosis | Apicidin |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Paeonol | Naringin | L-Ascorbic acid sodium salt | Alginic acid | Gefitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$299.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2025-06-17 |
United States