Product Details
| Product Name:
AP20187 |
CAS No.:
195514-80-8 |
| Purity:
99.80% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | AP20187 |
| Description | AP20187 (B/B Homodimerizer) is a cell-permeable compound used to dimerize FK506-binding protein (FKBP) fusion proteins, thereby initiating biological signaling cascades, gene expression, or disrupting protein-protein interactions. |
| In vitro | Treatment of LNCaP cells with AP20187 (B/B Homodimerizer) at a concentration of 100 nM significantly reduces ro-iCaspase-9 levels, while the smaller, processed, active form of caspase-9 becomes evident. |
| In vivo | Treatment with AP20187 significantly mitigates the effects of experimental autoimmune encephalomyelitis (EAE) on myelin sheaths in mice, markedly decreasing the prevalence of deteriorating axons and enhancing axonal density within demyelination sites in the lumbar spinal cord of PLP/Fv2E-PERK mice. Additionally, real-time PCR analysis reveals that AP20187 (B/B Homodimerizer) administration at doses of 0.5 mg/kg, 2 mg/kg, or 5 mg/kg notably elevates CHOP mRNA levels in the central nervous system (CNS) of PLP/Fv2E-PERK mice at post-infection day (PID) 12. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (37.09 mM)
Ethanol : 130 mg/mL (87.67 mM), Sonication is recommended.
|
| Keywords | AP 20187 | AP20187 | inhibit | AP-20187 | FKBP | FK506-binding protein | Inhibitor |
| Related Compound Libraries | Bioactive Compound Library | NO PAINS Compound Library | PPI Inhibitor Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$89.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
|
|
$0.00/100MG |
VIP1Y
|
Hubei Chuchang Biotech Co., Ltd.
|
2024-04-17 |
United States