Anticancer agent 105 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-16 |
Product Details
| Product Name: Anticancer agent 105 | CAS No.: 2450987-57-0 |
| Supply Ability: 10g | Release date: 2025/05/16 |
Product Introduction
Bioactivity
| Name | Anticancer agent 105 |
| Description | Anticancer agent 105, a thienopyrimidine scaffold-based compound, exhibits selective toxicity towards melanoma and induces apoptosis. Additionally, it significantly inhibits metastatic nodules, including in a pulmonary metastatic melanoma mouse model [1], while demonstrating good safety and anticancer properties. |
| In vitro | Anticancer agent 105 (compound 9cb) shows selectivity against cancer cells with an IC50 of 2.41 μM for B16-F10 melanoma cells, while exceeding 100 μM for normal fibroblasts (MEF NF2) [1]. At 0.5-10 μM over 24 hours, it exhibits cytotoxic effects on cancer cells, and at 5-20 μM over 48 hours, it induces apoptosis and necrosis in B16-F10 cells [1]. |
| In vivo | Anticancer agent 105 [compound 9cb] at a dosage of 9-9.5 mg/kg administered intraperitoneally every three days for a duration of 22 days, inhibited metastatic nodules in C57BL/6 mice bearing B16-F10 melanoma [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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