Product Details
| Product Name:
Anifrolumab |
CAS No.:
1326232-46-5 |
| Purity:
> 95% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Anifrolumab |
| 描述 | Anifrolumab（MEDI-546） is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of type I interferon and is used for the prevention and treatment of systemic lupus erythematosus (SLE). |
| 體外活性 | Anifrolumab induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation at a concentration of 67.7?nM for 20 minutes[1].
Anifrolumab suppresses the differentiation of B cells into plasma cells at concentrations of 1 and 10 μg/mL for 6 or 7 days[1].
Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50s ranging from 0.004 to 0.3?nM for the IFN-α subtypes, and 0.03?nM and 0.07?nM for IFN-β and IFN-ω, respectively[1].At a concentration of 67.7?nM, Anifrolumab dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production[1]. |
| 存儲條件 | store at low temperature | store at -80°C | Shipping with blue ice. |
| 溶解度 | DMSO : 60.00 mg/mL, Sonication is recommended.
|
| 關(guān)鍵字 | MEDI546 | MEDI 546 | MDX1333 | MDX 1333 | Anifrolumab |
| 相關(guān)產(chǎn)品 | IFN alpha-IFNAR-IN-1 hydrochloride | Deucravacitinib | Ginsenoside F3 | RO8191 | CP-28888 | Tilorone dihydrochloride | AX-024 hydrochloride | Interferon receptor inducer-1 | Vadimezan | Monalizumab | Cridanimod | CCCP |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:47439-36-1
$79.00 / 1mg
-
CAS:2170136-65-7
$43.00 / 1mg
-
CAS:1872382-48-3
$32.00 / 1mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States