Aminooxyacetic acid hemihydrochloride NEW
| Price | $41 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Aminooxyacetic acid hemihydrochloride | CAS No.: 2921-14-4 |
| Purity: 98.03% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Aminooxyacetic acid hemihydrochloride |
| Description | Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. |
| In vivo | At various intervals after aminooxyacetic acid(AOAA) the rats were either injected with one of the convulsive drugs or sacrificed for analysis of the GABA concentration.?AOAA caused a rapid initial (0-30 min) and a later slower increase of GABA in cerebellum and whole brain.?In the synaptosomal fraction the GABA accumulation was delayed and less pronounced when compared to the whole brain.?The bicuculline induced convulsions were markedly potentiated during the first hour but completely blocked from 2-6 h after AOAA.?Picrotoxin showed a somewhat different pattern to bicuculline in the interactions with AOAA.?The initial strong potentiation was not observed but the later phase of protection was present.?In the interactions with 3-MPA, the effect of AOAA was always protective.?The time to onset of convulsions was gradually increased during the first 30 min after AOAA.?This protective effect remained practically unchanged up to 6 h after AOAA.?However, once started, the convulsions were generally of the same duration and intensity.?The results can be interpreted as GABA accumulating after AOAA stimulates GABA receptors to a degree more or less proportional to the whole brain GABA concentration and further that GABA synthetized in neurons is liberated, stimulates inhibitory bicuculline sensitive (predominant) and excitatory bicuculline insensitive receptors and is captured to a large extent by non-neuronal cells[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (411.71 mM) |
| Keywords | Aminooxyacetic acid hemihydrochloride | γ-Aminobutyric acid Receptor | Aminooxyacetic acid | Aminooxyacetate hemihydrochloride | Inhibitor | inhibit | GABA Receptor | Carboxymethoxylamine | Aminooxyacetic acid Hemihydrochloride | Gamma-aminobutyric acid Receptor |
| Inhibitors Related | Valproic acid sodium salt | Penicillin G sodium salt |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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